Vaccine production


Viral vaccines are used globally to protect humans against infections. Vaccines are made by first growing a virus in an egg-based or cell-based process. The virus is then inactivated or attenuated, concentrated and purified, before it is finally blended with other components for making the final vaccine formulation.

Purification is one of the most important operations, as it removes impurities originating from host cells or culture media and ensures the safety and efficiency of the final product. It is also one of the costliest steps in manufacturing. Sucrose gradient centrifugation is widely used for the purification and concentration of viruses in large scale production.

Vaccine production

Download our application note and learn how, by utilizing real-time concentration measurements by Vaisala Polaris™ Refractometer, pharmaceutical manufacturers can:


  • Reliably isolate virus fractions in the purification phase
  • Ensure high-quality vaccines 
  • Increase yield and productivity

The Polaris refractometer is a valuable PAT tool during research and development phase. The application note explains the benefits of using refractive index in downstream operations of vaccine production. The note also includes recommended installation points for best performance.

Download the application note (PDF) by filling the form.

Watch our webinar on Fast and efficient viral vaccines purification by sucrose density gradient

Discover all applications in Pharmaceutical drug manufacturing and biotechnology processes.

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