Sensor Breakdown for Chambers Vs Room Monitoring: What Sensors are best for Your Application?

Paul Daniel, Vaisala
Senior GxP Regulatory Compliance Expert
Industrial Manufacturing and Processes
Industrial Measurements
Life Science

Many chamber applications are cold temperature applications and usually temperature is the only parameter monitored.  Cold air cannot hold much moisture so it is uncommon to use a humidity sensor in a cold temperature situation. 

There are four different sensor types commonly used for cold temperature monitoring:

  • Mercury or alcohol thermometer
  • Thermistor (thermal resistor)
  • Resistance temperature detectors (RTDs) usually made from a pure metal, such as platinum, copper or nickel, around a ceramic or glass core
  • Thermocouple, two wires of different metals. The junction between the two metals will show a voltage change from a change in temperature.Cold temperature data logger Vaisala

In our experience, when folks want to monitor cold temperatures, they simply select a vendor, then accept the sensor type that the vendor has decided will work best in that particular application.  So, in many cases the decision of what sensor to use is based on your choice of vendor.  Monitoring does not require a high accuracy sensor for most applications, especially for cold temperatures, so most types of sensors can be used with equal efficacy. However, it can be valuable to understand how each of the four types of sensors work in case there are variables in your environments that will cause one sensor to function better, last longer, and measure more accurately.

Glass thermometers, while simple, reliable, and inexpensive, are used less often in industrial applications because they require human labour for daily checks, data recording, and manual reporting.  Obviously, these tasks are rife with opportunity for error.   However, thermometers are still used in emerging nations where labour is inexpensive and higher tech solutions are prohibitively expensive. Thermistors, RTDs (Resistance Temperature Detector), and thermocouples are electronic versions of the thermometer.  The temperature causes the electrical characteristics of the sensor to change, thereby allowing us to determine the temperature by measuring an electrical value, such as resistance. 

These devices vary widely in terms of cost, initial accuracy, long-term stability, and range.  For most applications in monitoring cold temperatures (8°C to -80°C), a device equipped with an RTD or a thermistor would be selected. For instance, the Wi-Fi data logger HMT140 uses RTDs that measure from  -200°C to +200°C with good accuracy (+/-0.5°C over that range).  For very cold applications, such as liquid nitrogen cryogenic applications, a thermocouple can be used due to the extreme cold (as low as -196°C). 


Here is a rough breakdown of the differences between the types of temperature sensors.  These are general and subject to disagreement.

  • Thermocouples – inexpensive, linear response to temperature changes (easy to calibrate), relatively low accuracy, low stability, very wide range of temperatures that can be measured, durable, energy efficient (takes little energy to operate). Good for extreme temperatures like freezers, very low-temperature applications, ovens, etc.
  • Thermistors – inexpensive, non-linear response (harder to calibrate), high accuracy, high stability, narrow range of temperatures, durable, energy efficient. Excellent for ambient, controlled room temperature.
  • RTDs – expensive, linear response, high accuracy, high stability, moderate range of temperatures, fragile, energy inefficient (needs external power). Also good for controlled room temperature, ambient monitoring.

The measurements from these electronic sensors are typically measured by a device like a chart recorder or a data logger.  Chart recorders — due to the labour requirements of changing charts and the real possibility of mechanical failure — seem to be disappearing from the field, though they are still quite popular in some countries.  We have a chart recorder replacement calculator tool that shows the costs of running these, versus the cost of data loggers.

Currently, the most modern method is to collect the data from the electronic sensor and store it in a logger for later collection and download.  The data logger is generally considered to be superior because there is a very low risk of data loss.  The downside of the data logger is that we need to download the data.  This disadvantage of the data logger was mitigated with the advent of automated monitoring systems where data is automatically downloaded over a network connection. No more walking from sensor to sensor, no more compiling manual reports.

Humidity is another beast altogether. It is measured in both ambient and chamber applications, although as stated, because of temperature dependency it's rarely measured in low temperatures. As a parameter, humidity is both simpler and more complex. It's simple because when you measure humidity, you will almost always use sensor based on a thin-film capacitor. It's complex because the sensors are prone to drift. Achieving accuracy in humidity sensors is time-consuming and expensive because, unlike a temperature sensor, the sensor is degraded by the environment.  When both temperature and humidity are measured, a thin-film capacitor humidity sensor is combined with a thermistor or RTD. Just a final note on thin-film capacitor measurement technology, which was pioneered by Vaisala. We manufactured the first solid state humidity sensor in 1973.  

For more information on choosing humidity instruments and understanding the nature of that measurement, we have these articles:

Questions? Email Paul Daniel.


NEW ISPE Good Practice Guide:
Controlled Temperature Chamber Mapping and Monitoring

Vaisala's Senior Regulatory Expert Paul Daniel was part of the ISPE team that produced the new Good Practice Guide.  We are pleased to have been asked to participate in the creation of this new useful guide and proud to have our instruments featured on the cover. 

The ISPE Good Practice Guide: Controlled Temperature Chamber Mapping and Monitoring provides industry good manufacturing practices for temperature mapping controlled temperature chambers, along with development of test acceptance criteria and a risk-based approach to practices for periodic review of system performance.

There is an increased regulatory interest in cold chain driven by the growing number of products requiring controlled temperature shipping and storage, the complexity of the distribution network for the products and governmental requirements for distribution of vaccines. In this guide, you will find information on:

    Provision of industry good manufacturing practices for the temperature mapping of controlled temperature chambers, considering the impact of load, and the use of the data to determine the location and number of monitoring sensors

    Development of test acceptance criteria

    A risk-based approach to practices for periodic review of system performance

LEARN ABOUT Vaisala mapping and monitoring solutions.



Paul Daniel, Vaisala

Senior GxP Regulatory Compliance Expert

Paul Daniel has worked in the GMP-regulated industries for over 25 years helping manufacturers apply good manufacturing practices in a wide range of qualification projects.  His specialties include mapping, monitoring, and computerized systems.  At Vaisala, Paul oversees and guides the validation program for the Vaisala viewLinc environmental monitoring system.  He serves as a customer advocate to ensure the viewLinc environmental monitoring system matches the demanding requirements of life science and regulated applications.  Paul is a graduate of University of California, Berkeley, with a bachelor’s degree in biology.

Jon Aldous

Senior Product Manager

Jon Aldous was the product manager for Vaisala’s Continuous Monitoring systems. His background includes electronics and electrical science with a Bachelor of Engineering. He taught digital and mechanical engineering at the University of the West of England. He also worked on the development of poly-silicon micro structures used within thermopiles and intelligent data acquisition sensors.

After immigrating to the US, he worked for 12 years with Kaye Instruments as the lead product manager developing thermal validation systems. He joined Veriteq Instruments, which was acquired by Vaisala in 2010. During his time at Vaisala Jon’s role has expanded to oversee the research and continuous development of software and hardware for Vaisala’s environmental monitoring systems. 

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