vH2O2 Bio-decontamination: Optimizing Cycle Development in Aseptic Isolators

vH2O2 Bio-decontamination Cycle Development in Isolators
Industrial Manufacturing and Processes
Industrial Measurements
Life Science

Vaporized hydrogen peroxide is an effective antimicrobial that also destroys fungal spores, bacterial endospores, and viruses. While isolators prevent contamination, to maintain aseptic conditions, vH2O2 bio-decontamination is performed on the internal surfaces of the isolator and the exposed, external surfaces of the materials and equipment placed within. Understanding and controlling process conditions throughout all phases of vH2O2 bio-decontamination is crucial to effective log kills.

To develop an effective bio-decontamination cycle, measurements of process conditions like temperature, humidity, vH2O2 concentration (ppm), and condensation point are necessary.  In addition to measuring and monitoring parameters, an understanding of aseptic techniques, glove management, isolator preparation, process indicators, and validation are all important to successful vH2O2 bio-decontamination processes. 

In this webinar, Vaisala Product Manager Joni Partanen is joined by Rick Nieskes of Ardien Consulting. Rick brings over thirty years of industry experience to show how to optimize cycle development for vH2O2 bio-decontamination in pharmaceutical isolators. Joni will describe the unique technology of Vaisala's vH2O2 sensor and the importance of calibration and maintenance of these sensors, exposed to the demanding conditions of vH2O2 bio-decontamination.

After the webinar, our presenters shared their Q&A in these two blogs:

Part 1 – Questions & answers on vH2O2 bio-decontamination in aseptic isolators
Part 2 – Questions & answers on vH2O2 bio-decontamination in aseptic isolators

Key Takeaways:                                                      
• Excess vs acceptable condensation of vH2O2

• How to prepare and validate the isolator

• How to adopt a “Quality In = Quality Out” approach

• Achieving consistent critical phase values: Relative saturation, relative humidity, mixture dewpoint, temperature, etc.

• How to find opportunities to decrease sampling with biological, chemical, or enzymatic indicators

• The benefits of monitoring between validations

• Calibration of PEROXCAP® sensor technology  vs. Electrochemical cell technology

 

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Vaisala Product Manager Joni Partanen

Joni Partanen

Vaisala Product Manager

Joni Partanen is overseeing the development of industrial instruments for the life-science and pharmaceutical industries. With technical expertise and two decades of experience in process industry measurement technology, industrial engineering, and instrumentation, Joni brings a wealth of knowledge to the role. Joni holds a Bachelor of Engineering degree in Automation Technology.