Solvent swap or solvent exchange

Solvents are used in many Active Pharmaceutical Ingredients (APIs) manufacturing processes. They enable the desired chemical reaction, and solvents are also used during separation and purification steps.

Download our application note and learn how, by utilizing real-time concentration measurements by Vaisala K-PATENTS® Pharma Refractometer, the pharmaceutical manufacturers can:

  • Determine the point for solvent swap addition.
  • Control concentration in real time during solvent swap operations.
  • Obtain process profiles for process validation, troubleshooting and optimization.
  • Optimize solvent consumption while keeping the total separation rate stable.
  • Minimize energy consumption during operation.
  • Gain process understanding on vapor-liquid equilibrium (VLE) to help to scale-up the process.

The application note explains in more detail the benefits of using refractive index measurement technique. The note also includes recommended installation points for best performance, and shortly introduces the reliable technology our pharma refractometer is based on.

Download the application note (PDF) by filling the form.

Discover all applications in Pharmaceutical drug manufacturing and biotechnology processes.

Solvent swap or solvent exchange

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