Refractive Index as a PAT tool for peptide and oligonucleotide synthesis
Two time options
Improve process visibility in peptide and oligonucleotide synthesis with real-time refractive index measurement.
Peptide and oligonucleotide manufacturing processes are highly repetitive, solvent-intensive, and increasingly dependent on reliable process analytical technology. In solid-phase peptide synthesis and oligonucleotide synthesis, each coupling, deprotection, and washing step changes the liquid-phase composition. These changes can provide valuable process information when they are measured continuously.
In this webinar, we explain how inline refractive index measurement can be used as a PAT tool to monitor liquid-phase concentration changes in real time. The session covers how continuous concentration measurement can help process development, PAT, CMC, and manufacturing teams
- improve process understanding,
- identify synthesis step endpoints
- track washing progress, and
- evaluate opportunities to reduce solvent consumption.
Join the webinar to learn how refractive index technology can support smarter process decisions from laboratory development to scale-up and pharmaceutical manufacturing.
Read more: Pharmaceutical drug manufacturing and biotechnology processing
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Webinar Speaker: Tamara Murusidze
Tamara Murusidze is a Sales Manager for Liquid Measurement in the Global Life Science market at Vaisala. She supports biopharmaceutical and life science organizations in applying inline measurement technologies to improve process understanding, control, and efficiency.
With over 15 years of experience in liquid analysis and process instrumentation, Tamara has held both technical and commercial roles across Europe. Prior to Vaisala, she served as Product Manager in the Liquid Analysis Division at Tecnova HT, specializing in inline concentration measurement using refractive index, ultrasound velocity, and optical methods, as well as viscosity, turbidity, and wastewater monitoring technologies. Tamara holds a Professional Master’s Degree in the Commercialization of Scientific Instruments from Aix-Marseille University and a degree in Electronics from the National Technical University of Ukraine (Kyiv Polytechnic Institute).
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