Real-Time Protein Concentration Control in UF/DF and SPTFF with Inline Refractive Index

Life Science

Liquid Measurements

Join Vaisala's Tamara Murusidze and guest speaker Yik Lam of Biogen to learn how inline refractive index supports confident protein concentration monitoring in ultrafiltration/diafiltration (UF/DF) and single-pass tangential flow filtration (SPTFF) processes. You will learn where conventional approaches create risk, how inline RI works as a PAT tool, and what to consider when implementing it from process development through manufacturing scale.

As protein concentrations rise and downstream processes become more intensified, delayed offline measurements and indirect estimates can introduce uncertainty into critical concentration decisions. In ultrafiltration, diafiltration, and single-pass tangential flow filtration, inline refractive index (RI) offers a practical way to move from estimation to real-time measurement.

This webinar is designed for:

Bioprocess engineers
Downstream scientists
Process development teams
MSAT professionals
Biotech professionals working to improve concentration control, process visibility, and scale-up confidence.

What you will learn:

How offline and model-based concentration methods are complemented by refractive index in UF/DF and SPTFF
How inline RI can be applied across development, scale-up, and GMP manufacturing
Practical considerations for implementation, calibration, and system integration
How this approach has been evaluated in commercial-scale bioprocessing environments

Register to learn how inline refractive index can help bring greater confidence, faster insight, and stronger process control to protein concentration measurement in modern downstream bioprocessing.

If you have already attended or registered for this webinar, please click here. Otherwise, please watch the recorded webinar by filling the form.

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Webinar Speaker: Tamara Murusidze

For more than 15 years, Tamara Murusidze has helped process engineers measure what happens inside their liquids, as it happens. She specializes in inline liquid analysis for biopharmaceutical and chemical pharmaceutical production, where real-time concentration data gives teams tighter process control and fewer surprises at the end of a batch.

At Vaisala, Tamara works with biopharma and life science manufacturers to apply inline refractive index measurement across development, scale-up and production. Before joining Vaisala, she was Product Manager in the Liquid Analysis Division at Tecnova HT. There she specialized in inline concentration measurement using refractive index, ultrasound velocity and optical methods, along with viscosity, turbidity and wastewater monitoring.

Her background spans both technical and commercial roles across Europe, so she understands the measurement physics as well as the realities of the production floor. Tamara holds a Professional Master’s Degree in the Commercialization of Scientific Instruments from Aix-Marseille University and a degree in Electronics from the National Technical University of Ukraine (Kyiv Polytechnic Institute).

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Yik Lam is a Senior Engineer in Technical Development at Biogen (Research Triangle Park, NC), with deep expertise in downstream purification development and technology transfer to manufacturing scale. His work focuses on non-chromatographic separation processes—including harvest, normal flow filtration (NFF), and tangential flow filtration (TFF/UF-DF)—as well as process automation and development of new downstream technologies. He is a co-author on Biogen’s 2023 paper examining UF/DF membrane performance for processing antisense oligonucleotides, reflecting his applied experience in scaling filtration-based unit operations for modern modalities.

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