Differential Pressure in Cleanrooms: From Regulatory Expectations to Defensible Monitoring Records

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Life Science

What most people miss about cleanroom differential pressure monitoring. 

Learn how differential pressure monitoring affects measurement certainty, alarming, and audit defensibility in regulated cleanroom environments. In this webinar we describe why the method of monitoring differential pressure matters and how building automation systems and environmental monitoring systems differ. 

In this webinar, Sean Murphy, Senior Project Sales Engineer at Vaisala, explains how cleanroom differential pressure monitoring works in practice and why monitoring systems have a major impact on uncertainty, short-term pressure fluctuations, alarm performance, and reports for regulatory compliance. 

Learn the difference between common-reference calculated dP and direct room-to-room measurement and why low-pressure cleanroom applications benefit from careful sensor placement and system design. Sean will also show how BAS/BMS and environmental monitoring systems can contribute to a complete monitoring strategy.

Attendees will leave with a better understanding of installation choices, tubing layout, access to sensors for calibration, and alarm strategy.  You'll also see how a continuous environmental system can support secure data recording, alarming, and audit-ready documentation.

What you will learn

  • The difference between monitoring methods:  common-reference calculated dP and direct room-to-room dP 
  • Why measurement uncertainty matters in low-pressure cleanroom applications
  • How dynamic events such as door openings can affect readings and alarm behavior
  • What to consider when selecting measurement points, tubing layout, and installation location
  • Practical differences between BAS/BMS control systems and independent Continuous Monitoring Systems (CMS) 
  • How to ensure audit-ready differential pressure monitoring records for regulated cleanrooms

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Sean Murphy Senior Project Sales Engineer

Sean Murphy, Vaisala

Senior Project Sales Engineer

Sean Murphy is a Senior Project Sales Engineer at Vaisala with extensive experience in environmental monitoring systems for pharmaceutical manufacturing, medical device manufacturing, and other highly regulated critical environments. Over the course of his career, he has worked in application engineering, project sales, system design, and integration, helping customers implement monitoring solutions that align with operational and compliance needs.

At Vaisala, Sean has held a range of roles across project management, field service coordination, applications, and system delivery. His experience includes system design review, project documentation, customer site preparation, installation coordination, and the development of engineered solutions for continuous monitoring applications.

Sean also brings a strong background in analytical chemistry, scientific instrumentation, and technical presentations. His practical knowledge of monitoring system architecture and customer implementation gives him a valuable perspective on how environmental monitoring solutions are applied in demanding cleanroom and regulated settings.