Continuous Inline RI for UF/DF, DF, and SPTFF Protein Concentration

Make UF/DF measurable while it’s happening

UF/DF and SPTFF are decision-heavy steps where small concentration errors can snowball into downstream issues—viscosity surprises, membrane stress, fouling risk, rework, or yield loss. Yet concentration control is still often estimated, delayed, and operator-dependent, with decisions made after the fact.

This webinar focuses on continuous inline measurement—not to replace analytics, but to reduce uncertainty and increase confidence while the process is running. The core question we’ll explore is:
Can we measure concentration inline, continuously, without adding complexity?

What you’ll learn: 

• Refractive index as PAT: what RI measures, how it works, and why it’s a robust physical measurement (linear, temperature-compensated, dilution-free; not impacted by color/turbidity)
• Where traditional approaches strain: why offline sampling and A280-based approaches can break down as titers and viscosity increase (sampling/dilution error, scattering, practical limits)
• Why RI is especially valuable in UF/DF & SPTFF: how real-time RI trends help verify assumptions, detect drift, and support tighter endpoint decisions
• Handling real-process complexity: how to think about buffer/matrix effects and practical compensation approaches (calibration strategies, reference measurements)
• Implementation from R&D to GMP: feasibility testing, validation approach, and what scale-up looks like
• High-level installation & integration: mounting options, hygienic connections, CIP/SIP considerations, and signals (4–20 mA, digital comms)

Q&A Session: bring your toughest questions

Who should attend

This webinar is designed for downstream teams working with UF/DF, TFF, or SPTFF, including:

• Process Development, MSAT, and Manufacturing
• Downstream/Purification engineers
• Tech Ops and process control teams
• QC / Analytics professionals supporting TFF operations