Aseptic isolators are essential in pharmaceutical manufacturing, sterility testing, cell therapy, and tissue banking. To maintain sterility, isolators must undergo regular bio-decontamination—most commonly using vaporized hydrogen peroxide (vH₂O₂) due to its broad-spectrum efficacy and non-residual behavior.
Achieving consistent, validated vH₂O₂ cycles depends on precise control of environmental conditions, especially humidity and relative saturation (%RS). Traditional relative humidity (RH) alone is not sufficient when hydrogen peroxide vapor is present.
Why Relative Saturation Is Critical
Relative Saturation (%RS) accounts for both water vapor and vH₂O₂ vapor, providing a true indication of proximity to condensation. vH₂O₂ efficacy is highest near the condensation point—typically 80% RS or higher—but excessive condensation can compromise the isolator environment and equipment. Monitoring %RS enables operators to maximize microbicidal performance while avoiding unwanted condensation.
Precision Monitoring of vH2O2
The Vaisala HPP272 probe provides an integrated measurement approach that supports reproducible cycles, robust validation, and compliance in regulated environments.
What You’ll Learn
- Why %RS is the most relevant control parameter for vH₂O₂ bio-decontamination
- How humidity, temperature, and vH₂O₂ interact in isolator cycles
- Best practices for monitoring, validation, and documentation
Download the Application Note to learn how accurate %RS measurement improves vH₂O₂ bio-decontamination performance in aseptic isolators.
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