A recipe and a timer can't tell you when the last powder has dissolved or when a buffer has hit its target. Most teams wait on offline samples to find out, while the mixer keeps running and the vessel stays tied up. Conductivity and pH help, yet neither one sees nonionic components such as sugars.
This application note shows how inline refractive index (RI) measurement with Vaisala Polaris™ process refractometers turns media and buffer preparation into a measured process, from the first ingredient addition to transfer.
Download the application note to learn:
- How the RI trend reveals each addition, dissolution progress and the real endpoint
- Why RI sees the sugars and other nonionic components that conductivity and pH miss
- How a recipe-specific link between RI and offline osmolality supports PAT and a path to real-time release
- Where to install PR53AP and PR53AC refractometers, and how to set robust RI targets
- What continuous RI means for cycle times, rejected batches and batch-to-batch consistency
Download the application note by filling the form
You can modify your preference settings or unsubscribe at any time here